745Risk of Peripheral Blood Eosinophilia and Hypersensitivity Reactions among Patients Receiving Outpatient Parenteral Antibiotics

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745Risk of Peripheral Blood Eosinophilia and Hypersensitivity Reactions among Patients Receiving Outpatient Parenteral Antibiotics

BACKGROUND Although drug-induced peripheral eosinophilia complicates antimicrobial therapy, little is known about its frequency and implications. OBJECTIVE We aimed to determine the frequency and predictors of antibiotic-induced eosinophilia and subsequent hypersensitivity reactions (HSRs). METHODS We evaluated a prospective cohort of former inpatients receiving intravenous antibiotic thera...

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Background Hypersensitivity reactions to parenteral administered antibiotics (HRPA) are a substantial problem in managing pulmonary disease in Cystic Fibrosis (CF), especially in advanced CF. This group of patients requires a life long antibiotic treatment with extremely high cumulative doses compared to other patients. In our daily routine we observed a growing number of hypersensitivities. Th...

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Prediction model for 30-day hospital readmissions among patients discharged receiving outpatient parenteral antibiotic therapy.

BACKGROUND Factors associated with readmission for patients prescribed outpatient parenteral antibiotic therapy (OPAT) at hospital discharge have not been definitively identified. The study aim was to develop a model of 30-day readmissions for OPAT patients. METHODS A database comprising 782 OPAT patients treated between 2009 and 2011 at a single academic center was created. Variables collect...

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1298Predictors of Hospital Readmission in Patients Receiving Outpatient Parenteral Antimicrobial Therapy (OPAT)

Background. OPAT is increasingly utilized; however, hospital readmissions during OPAT are common and few studies have been conducted to identify risk factors for these readmissions. Methods. Retrospective, observational, cohort study of adults discharged from a U.S. academic medical center between 1/1/12 – 8/1/13 who received OPAT via a peripherally inserted central catheter. Cystic fibrosis pa...

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757Comparison of Nephrotoxicity in Outpatient Parenteral Antimicrobial Therapy (OPAT) Patients Receiving Beta-lactams or Vancomycin

Background. Outpatient parenteral antimicrobial therapy (OPAT) programs are growing as a cost-effective, safe, and practical way to treat patients with complicated infections outside of the hospital. The guidelines for therapeutic monitoring of vancomycin state that there is minimal difference in incidence of toxicity between vancomycin and beta-lactams. However, there are few studies describin...

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ژورنال

عنوان ژورنال: Open Forum Infectious Diseases

سال: 2014

ISSN: 2328-8957

DOI: 10.1093/ofid/ofu052.453